A patient in Israel is administered Prof. Nadir Arber’s EXO-CD24 COVID-19 treatment. Ichilov Medical Center in Tel Aviv says it may have found Covid-19 cure. (PHOTO: Ichilov spokesperson’s office).
A new coronavirus treatment being developed at Tel Aviv’s Ichilov Medical Center has successfully completed phase 1 trials and appears to have helped numerous moderate-to-serious cases of COVID-19 quickly recover from the disease, the hospital said Friday.
Hailing a “huge breakthrough,” the hospital said Prof. Nadir Arber’s EXO-CD24 substance had been administered to 30 patients whose conditions were moderate or worse, and all 30 recovered — 29 of them within three to five days.
The medicine fights the cytokine storm — a potentially lethal immune overreaction to the coronavirus infection that is believed to be responsible for much of the deaths associated with the disease.
It uses exosomes — tiny carrier sacs that shuttle materials between cells — to deliver a protein called CD24 to the lungs, which Arber has spent decades researching.
“This protein is located on the surface of cells and has a well known and important role in regulating the immune system,” said researcher Shiran Shapira of Arber’s lab.
The protein helps calm down the immune system and curb the storm.
“The preparation is inhaled once a day for a few minutes, for five days,” Arber said. “The preparation is directed straight to the heart of the storm — the lungs — so unlike other formulas… which selectively restrain a certain cytokine, or operate widely but cause many serious side effects, EXO-CD24 is administered locally, works broadly and without side effects.”
The medicine will now move on to further trial phases, but hospital officials were already hailing it as a possible game-changer in fighting serious COVID-19 illness.
Ichilov director Roni Gamzu, the former coronavirus czar, said the research “is advanced and sophisticated and may save coronavirus patients. The results of the phase 1 trial are excellent and give us all confidence in the method [Arber] has been researching in his lab for many years.”
He added: “I am proud that at Ichilov we are… possibly bringing a blue and white remedy to a terrible global pandemic.”
Despite what has been termed the world’s fastest vaccination campaign per capita, Israel has still been registering a daily average of 6,500 new Covid-19 cases, down from around 7,000 last week, official figures show.
A strict nationwide lockdown in force since December 27 has been extended four times to combat the infection rate, but January was the deadliest month with more than 1,000 Covid fatalities.
According to latest figures from the health ministry, Israel has registered a total of more than 675,000 cases of Covid-19, including 5,019 deaths.
Reporting by The Times of Israel, Daily Mail.
